Adhesion of T and B Lymphocytes to Extracellular Matrix and Endothelial Cells Can Be Regulated Through the (Beta) Subunit of VLA

In a study investigating the regulation of very late antigen (VLA)-mediated functions, it was found that TS2/16, a mAb directed against the beta chain of the VLA group of integrins, can induce binding of resting peripheral blood lymphocytes, cloned T lymphocytes and Epstein Barr virus-transformed B...

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Bibliographic Details
Published inThe Journal of cell biology Vol. 117; no. 2; p. 461
Main Authors van Kooyk, Yvette, Weder, Pauline
Format Journal Article
LanguageEnglish
Published New York Rockefeller University Press 01.04.1992
Subjects
Cellular biology
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Summary:In a study investigating the regulation of very late antigen (VLA)-mediated functions, it was found that TS2/16, a mAb directed against the beta chain of the VLA group of integrins, can induce binding of resting peripheral blood lymphocytes, cloned T lymphocytes and Epstein Barr virus-transformed B cells to extracellular matrix components, fibronectin, laminin and collagen, but not to fibrinogen.
ISSN:0021-9525
1540-8140