Mappin actin surfaces required for functional interactions in vivo

An in vivo strategy to identify amino acids of actin required for functional interactions with actin-binding proteins was developed. Genetic interactions between mutant alleles of the yeast actin gene and null alleles of the yeast SAC6, ABP1, SLA1 and SLA2 genes indicate that the effects of the 21 a...

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Bibliographic Details
Published inThe Journal of cell biology Vol. 126; no. 2; p. 423
Main Authors Holtzman, Douglas A, Wertman, Kenneth F, Drubin, David G
Format Journal Article
LanguageEnglish
Published New York Rockefeller University Press 01.07.1994
Subjects
Amino acids
Cellular biology
Genes
Mutation
Proteins
Yeast
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Summary:An in vivo strategy to identify amino acids of actin required for functional interactions with actin-binding proteins was developed. Genetic interactions between mutant alleles of the yeast actin gene and null alleles of the yeast SAC6, ABP1, SLA1 and SLA2 genes indicate that the effects of the 21 actin mutations are diverse.
ISSN:0021-9525
1540-8140