Regulation of RARbeta2 mRNA expression: Evidence for an inhibitory peptide encoded in the 5'-untranslated region

Reynolds et al have performed a systematic mutational analysis of the short upstream open reading frames (uORFs) to gain insight into the molecular mechanism underlying the mRNA translational regulation in RARbeta2 genes. Results suggest that the uORF4 amino acid coding sequence is important for the...

Full description

Saved in:
Bibliographic Details
Published inThe Journal of cell biology Vol. 134; no. 4; p. 827
Main Authors Reynolds, Kay, Zimmer, Anne M, Zimmer, Andreas
Format Journal Article
LanguageEnglish
Published New York Rockefeller University Press 01.08.1996
Subjects
Amino acids
Genes
Genetics
Molecular biology
Online AccessGet full text

Cover

More Information
Summary:Reynolds et al have performed a systematic mutational analysis of the short upstream open reading frames (uORFs) to gain insight into the molecular mechanism underlying the mRNA translational regulation in RARbeta2 genes. Results suggest that the uORF4 amino acid coding sequence is important for the inhibitory effect on translation of the downstream major ORF.
ISSN:0021-9525
1540-8140