CD3[zeta] Expression and T Cell Proliferation are Inhibited by TGF-[beta]1 and IL-10 in Cervical Cancer Patients
Issue Title: Special Issue on Innate Immunity in Aging; Editor: Dr. Sudhir Gupta, PhD Cervical cancer development from a squamous intraepithelial lesion is thought to be favored by an impaired T cell immunity. We evaluated parameters of T cell alterations such as proliferation, cytokine, and CD3ζ ex...
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Published in | Journal of clinical immunology Vol. 29; no. 4; p. 532 |
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Main Authors | , , , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
New York
Springer Nature B.V
01.07.2009
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Subjects | |
Online Access | Get full text |
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Summary: | Issue Title: Special Issue on Innate Immunity in Aging; Editor: Dr. Sudhir Gupta, PhD Cervical cancer development from a squamous intraepithelial lesion is thought to be favored by an impaired T cell immunity. We evaluated parameters of T cell alterations such as proliferation, cytokine, and CD3ζ expression in peripheral blood and tumor-infiltrating T lymphocytes from women with squamous intraepithelial lesions (SIL) or cervical cancer (CC). T cell proliferation and cytokine messenger RNA (mRNA) expression were similar in women with SIL and healthy donors, whereas low T cell proliferation and lower mRNA expression of IL-2, IL-10 and IFN-γ were observed in women with CC. Moreover, infiltrating cells showed marginal responses. We also found that CD3ζ mRNA expression, whose protein is required for T cell activation, correlated with a decreased proliferation in advanced stages of the disease. Experiments with T cells from healthy donors in the presence TGF-β1 or IL-10 suggest that these cytokines have a relevant role in T cell responses during CC progression. |
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ISSN: | 0271-9142 1573-2592 |
DOI: | 10.1007/s10875-009-9279-7 |