CD3[zeta] Expression and T Cell Proliferation are Inhibited by TGF-[beta]1 and IL-10 in Cervical Cancer Patients

• Published in: Journal of clinical immunology Vol. 29; no. 4; p. 532
• Main Authors: Díaz-benítez, Cinthya E, Navarro-fuentes, Karla R, Flores-sosa, Jacqueline A, Juárez-díaz, Janet, Uribe-salas, Felipe J, Román-basaure, Edgar, González-mena, Ludwig E, Alonso De Ruíz, Patricia, López-estrada, Guillermina, Lagunas-martínez, Alfredo, Bermúdez-morales, Victor H, Alcocer-gonzález, Juan M, Martínez-barnetche, Jesús, Hernández-pando, Rogelio, Rosenstein, Yvonne, Moreno, José, Madrid-marina, Vicente
• Format: Journal Article
• Language: English
• Published: New York Springer Nature B.V 01.07.2009
• Subjects: Cervical cancer
• ISSN: 0271-9142; 1573-2592
• DOI: 10.1007/s10875-009-9279-7

Issue Title: Special Issue on Innate Immunity in Aging; Editor: Dr. Sudhir Gupta, PhD Cervical cancer development from a squamous intraepithelial lesion is thought to be favored by an impaired T cell immunity. We evaluated parameters of T cell alterations such as proliferation, cytokine, and CD3ζ expression in peripheral blood and tumor-infiltrating T lymphocytes from women with squamous intraepithelial lesions (SIL) or cervical cancer (CC). T cell proliferation and cytokine messenger RNA (mRNA) expression were similar in women with SIL and healthy donors, whereas low T cell proliferation and lower mRNA expression of IL-2, IL-10 and IFN-γ were observed in women with CC. Moreover, infiltrating cells showed marginal responses. We also found that CD3ζ mRNA expression, whose protein is required for T cell activation, correlated with a decreased proliferation in advanced stages of the disease. Experiments with T cells from healthy donors in the presence TGF-β1 or IL-10 suggest that these cytokines have a relevant role in T cell responses during CC progression.