An infant with severe combined immunodeficiency syndrome, an [alpha]-thalassemia trait and renal Fanconi syndrome

We describe an infant with severe combined immunodeficiency syndrome and an alpha-thalassemia trait who developed a renal Fanconi syndrome after his first stem cell transplantation. This syndrome consists of a generalized failure of proximal tubular reabsorption, which leads to a large number of met...

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Bibliographic Details
Published inBone marrow transplantation (Basingstoke) Vol. 26; no. 1; p. 97
Main Authors van de Moesdijk, D, van Weel-Sipman, M H
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group 01.07.2000
Subjects
Stem cell transplantation
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Summary:We describe an infant with severe combined immunodeficiency syndrome and an alpha-thalassemia trait who developed a renal Fanconi syndrome after his first stem cell transplantation. This syndrome consists of a generalized failure of proximal tubular reabsorption, which leads to a large number of metabolic disturbances. The etiology varies from inherited causes, including an idiopathic form, to acquired causes such as intoxications, immunological disorders and hemoglobinopathies. In this case report we discuss possible explanations of the Fanconi syndrome in our patient.
ISSN:0268-3369
1476-5365
DOI:10.1038/sj.bmt.1702463