Inhibition of the (alpha beta) epithelial sodium channels by external protons indicates that the second hydrophobic domain contains structural elements for closing the pore
We have examined the effect of extracellular protons on the activity of epithelial sodium channels (ENaCs). We found that (alpha beta) channels, but not (alpha beta gamma) or (alpha gamma) channels, are inhibited by low extracellular pH.
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| Published in | Biophysical journal Vol. 77; no. 6; p. 3043 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
New York
Biophysical Society
01.12.1999
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| Subjects | |
| Online Access | Get full text |
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| Abstract | We have examined the effect of extracellular protons on the activity of epithelial sodium channels (ENaCs). We found that (alpha beta) channels, but not (alpha beta gamma) or (alpha gamma) channels, are inhibited by low extracellular pH. |
|---|---|
| AbstractList | We have examined the effect of extracellular protons on the activity of epithelial sodium channels (ENaCs). We found that (alpha beta) channels, but not (alpha beta gamma) or (alpha gamma) channels, are inhibited by low extracellular pH. |
| Author | Fyfe, Gregor K Grichtchenko, Irina I Canessa, Cecilia M Zhang, Pin |
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| Snippet | We have examined the effect of extracellular protons on the activity of epithelial sodium channels (ENaCs). We found that (alpha beta) channels, but not (alpha... |
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| Title | Inhibition of the (alpha beta) epithelial sodium channels by external protons indicates that the second hydrophobic domain contains structural elements for closing the pore |
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