Inhibition of the (alpha beta) epithelial sodium channels by external protons indicates that the second hydrophobic domain contains structural elements for closing the pore

We have examined the effect of extracellular protons on the activity of epithelial sodium channels (ENaCs). We found that (alpha beta) channels, but not (alpha beta gamma) or (alpha gamma) channels, are inhibited by low extracellular pH.

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Bibliographic Details
Published inBiophysical journal Vol. 77; no. 6; p. 3043
Main Authors Zhang, Pin, Fyfe, Gregor K, Grichtchenko, Irina I, Canessa, Cecilia M
Format Journal Article
LanguageEnglish
Published New York Biophysical Society 01.12.1999
Subjects
Biochemistry
Molecular biology
Protons
Sodium
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Summary:We have examined the effect of extracellular protons on the activity of epithelial sodium channels (ENaCs). We found that (alpha beta) channels, but not (alpha beta gamma) or (alpha gamma) channels, are inhibited by low extracellular pH.
ISSN:0006-3495
1542-0086