Changes in Dried Blood Spot Hb A^sub 1c^ with Varied Postcollection Conditions

Glycosylated hemoglobin (Hb A^sub 1c^), a cumulative marker of blood glucose concentrations over the previous 2 months, has become a powerful clinical tool for diabetes management (1, 2) and is predictive of future complications of diabetes (3). Epidemiologic studies have begun to use Hb A^sub 1c^ i...

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Published inClinical chemistry (Baltimore, Md.) Vol. 55; no. 5; p. 1034
Main Authors Buxton, Orfeu M, Malarick, Keith, Wang, Wei, Seeman, Teresa
Format Journal Article
LanguageEnglish
Published Washington Oxford University Press 01.05.2009
Subjects
Blood
Diabetes
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Womens health
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Summary:Glycosylated hemoglobin (Hb A^sub 1c^), a cumulative marker of blood glucose concentrations over the previous 2 months, has become a powerful clinical tool for diabetes management (1, 2) and is predictive of future complications of diabetes (3). Epidemiologic studies have begun to use Hb A^sub 1c^ in dried blood spots as a biomarker (4).We studied Hb A^sub 1c^ from dried blood spots by validating the storage conditions appropriate for large-scale epidemiologic/outreach studies to test the hypothesis that measurements of Hb A^sub 1c^ in dried blood spots are valid under low-intensity storage conditions.
ISSN:0009-9147
1530-8561