Acetogenins, alternative cancer treatment in dogs

Cancer is a disease that alter cellular processes, like cell metabolism, activation and deactivation of genes and uncontrolled growth. It is one of the main causes of death in humans, as well as in companion animals, which is why it is increasingly important to seek and develop medicines for the tre...

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Published inCES medicina veterinaria y zootecnia Vol. 13; no. 2; pp. 157 - 172
Main Authors Calle, Mónica Marcela Gaviria, Arias, Silvia Posada, Hernández, Juliana Mira
Format Journal Article
LanguageSpanish
Published Medellín Universidad CES 01.05.2018
Subjects
Animals
Annona muricata
Biological activity
Biotechnology
Cancer
Cancer therapies
Cell activation
Deactivation
Dogs
Flowers & plants
Gene silencing
Medical treatment
Metabolism
Metabolites
Natural products
Paclitaxel
Plants (botany)
Secondary metabolites
Taxol
Toxicity
Transcription activation
Tumor cell lines
Vincristine
Colombia
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Summary:Cancer is a disease that alter cellular processes, like cell metabolism, activation and deactivation of genes and uncontrolled growth. It is one of the main causes of death in humans, as well as in companion animals, which is why it is increasingly important to seek and develop medicines for the treatment. Some of the drugs that are produced to treat cancer come from plants, such as taxol and vincristine. The necessity to expand the use of natural products to treat this disease, not only in humans but also in companion animals such as dogs, opens the doors to seek biological activity of plants that are commonly used because they present some effect over the disease. This is the case of soursop (Annona muricata), from which secondary metabolites (acetogenins) have been extracted and have presented in vitro greater toxicity in cancer cell lines compared to normal cell lines. Therefore, this review was carried out in order to make an approximation of the uses of these metabolites in cancer, for which a search was carried out in PubMed with different key words and it was concluded that acetogenins comprise a potential source for the development of medicines against cancer.
ISSN:1900-9607
1900-9607
DOI:10.21615/cesmvz.13.2.5