O-109 Nebulized Adrenaline In 3% Hypertonic Saline Solution In Bronchiolitis: Is Safe?

• Published in: Archives of disease in childhood Vol. 99; no. Suppl 2; p. A66
• Main Authors: Flores-Gonzalez, J C, B Serrano Moyano, RM García Ortega, FJ Dávila Corrales, JJ Pérez Guerrero, L García García, E Palma Zambrana, P Comino Vazquez, P Rodriguez Campoy, MA Matamala Morillo, Garofano-Montero, S, Calvo-Morales, I M, AM Lechuga Sancho
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group LTD 01.10.2014
• Subjects: Bronchoconstriction; Bronchodilators; Bronchopneumonia; Clinical trials; Epinephrine; Heart rate; Infants; Respiratory therapy; Statistical analysis; Young Children
• ISSN: 0003-9888; 1468-2044
• DOI: 10.1136/archdischild-2014-307384.176

Background and aimsThe use of nebulized adrenaline in the treatment of infants with acute bronchiolitis, has been related to increased cardiac rate. On the other hand, bronchoconstriction episodes requiring bronchodilators have been reported with the use of nebulized 3% hypertonic saline solution (3%SSH) without bronchodilators. We aimed to analyse the safety of nebulized adrenaline and nebulized 3% HSS in the management of infants hospitalised for acute moderate bronchiolitis.MethodsRandomised, double-blind, controlled trial. 185 hospitalised infants (2.11 ± 2.23 months (mean ± SD) received nebulized 3%HSS (7ml) either with 3 mg of adrenaline (group SSH3%+A; n = 94) or 3 ml of placebo (group SSH3%+P; n = 91), in addition to routine therapy. Nebulizations were initially administered every four hours and adjusted thereafter according to clinical response. The principal outcomes measures were cardiac rate (CR) and frequency rate (FR) up to the median of stay, nebulization requirements and need of transfer to the PICU.ResultsThere was not statistically significant differences in the cardiac frequency (p = 0.76, 0.48 and 0.73, respectively) and frequency rate (p = 0.88, 0.07 and 0.24, respectively) in 3 days of median of stay, nebulizations rates (p = 0.89), PICU’s admission (p = 1). No other adverse events were reported.ConclusionIn acute bronchiolitis for moderately ill hospitalised infants, nebulized adrenaline and nebulized 3%HSS are safe.Abstract O-109 Table 1 CR(1d)CR(2d)CR(3d)FR(1d)FR(2d)FR(3d)Neb3%HHS+P1431431424949484.133%HHS+A1411421424947464.17p0.760.480.730.880.070.240.89