PS-020 Cardiac Function In Newborns With Fetal Growth Restriction: Morphological And Functional Changes

• Published in: Archives of disease in childhood Vol. 99; no. Suppl 2; p. A118
• Main Authors: L Rodriguez Guerineau, M Perez Cruz, Cambra, F J, Gómez, O, Carretero, J, MD Gomez Roig, Crispi, F, Bartrons, J
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group LTD 01.10.2014
• Subjects: Birth weight; Body Weight; Cardiovascular diseases; Children; Doppler effect; Fetuses; Gestational age; Health risk assessment; Morphology; Neonates; Statistical Significance
• ISSN: 0003-9888; 1468-2044
• DOI: 10.1136/archdischild-2014-307384.316

Background and aimsThe adaptive changes of the fetal heart in fetal growth restriction (FGR) could persist into childhood and be responsible for the increased cardiovascular mortality rate in adulthood. The aim of the study was to assess cardiac morphology and function in newborns with FGR.MethodsFGR was defined as a birth weight centile ≤ 10. Prospective study of 50 neonates, 25 with FGR and 25 with normal intrauterine growth and weight at birth (Table 1). Comprehensive echocardiographic study was performed assessing cardiac morphology, systolic and diastolic function.ResultsCompared with controls, neonates with FGR had more globular cardiac ventricles (Table 1), lower systolic excursions of the tricuspid and mitral valvular plane and lower values of the s’ in the lateral and septal mitral annulus in the tissue Doppler imaging (TDI) study (p < 0,05). The e’ at the tricuspid, lateral and septal mitral annulus together with the E wave of tricuspid inflow were significantly reduced in the FGR group; and tricuspid deceleration time showed a trend to increase without reaching statistical significance.ConclusionsNewborns with FGR manifest cardiac shape changes, reduced systolic values of the TDI at the left heart and lower values of diastolic function more pronounced at the right heart compared with neonates with normal intrauterine growth.Abstract PS-020 Table 1Characteristics (n = 50)FGR#Controls#pGestational age at birth(w = weeks + d = days)37w + 6d(34w–40w)39w + 4d(34w–41w)0,001Weight(kg)2,23(1,58–2,73)3,24(1,99–4,00)<0,001Right sphericity index1,56(1,11–2,28)1,90(1,53–2,46)<0,001Left sphericity index1,63(1,32–2,32)1,98(1,61–2,63)<0,001#Mean (Range).