Effect of Cysteine Protease Inhibitor Ep-475 on TNF-[alpha]-Independent Cyclophosphamide-Induced Apoptosis in Mouse Lymphosarcoma LS Cells

• Published in: Bulletin of experimental biology and medicine Vol. 139; no. 2; p. 186
• Main Authors: S. Ya. Zhanaeva, Korolenko, T A, Khoshchenko, O M, Spiridonov, V K, Nikolin, V P, Kaledin, V I
• Format: Journal Article
• Language: English
• Published: New York Springer Nature B.V 01.02.2005

Cyclophosphamide 1.5-2.0-fold increased activity of cathepsins B and L in tumor tissue of mouse lymphosarcoma LS and caused tumor regression. The effect was most pronounced on day 5 after treatment. Twofold treatment with a selective cathepsin inhibitor Ep-475 slightly stimulated tumor growth in con...