Effect of Cysteine Protease Inhibitor Ep-475 on TNF-[alpha]-Independent Cyclophosphamide-Induced Apoptosis in Mouse Lymphosarcoma LS Cells

Cyclophosphamide 1.5-2.0-fold increased activity of cathepsins B and L in tumor tissue of mouse lymphosarcoma LS and caused tumor regression. The effect was most pronounced on day 5 after treatment. Twofold treatment with a selective cathepsin inhibitor Ep-475 slightly stimulated tumor growth in con...

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Published inBulletin of experimental biology and medicine Vol. 139; no. 2; p. 186
Main Authors S. Ya. Zhanaeva, Korolenko, T A, Khoshchenko, O M, Spiridonov, V K, Nikolin, V P, Kaledin, V I
Format Journal Article
LanguageEnglish
Published New York Springer Nature B.V 01.02.2005
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Summary:Cyclophosphamide 1.5-2.0-fold increased activity of cathepsins B and L in tumor tissue of mouse lymphosarcoma LS and caused tumor regression. The effect was most pronounced on day 5 after treatment. Twofold treatment with a selective cathepsin inhibitor Ep-475 slightly stimulated tumor growth in control mice and significantly reduced the antitumor effect of cyclophosphamide. Lysosomal cysteine proteases cathepsins B and L are involved, but do not play a key role in TNF-α-independent apoptosis in LS cells induced by cyclophosphamide.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-005-0243-0