Effects of dimephosphone, xydiphone, and ionol on the content and activities of rat liver cytochromes P-450 during long-term treatment with phenobarbital
Effects of dimephosphone, xydiphone, and ionol administered in parallel with phenobarbital on the content of cytochromes P-450 in rat liver and on the rate of C-hydroxylation of diazepam, haloperidol, and prednisolone by rat liver microsomal enzymes were studied in vitro. Dimephosphone, xydiphone, a...
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Published in | Bulletin of experimental biology and medicine Vol. 138; no. 4; p. 393 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
New York
Springer Nature B.V
01.10.2004
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Online Access | Get full text |
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Summary: | Effects of dimephosphone, xydiphone, and ionol administered in parallel with phenobarbital on the content of cytochromes P-450 in rat liver and on the rate of C-hydroxylation of diazepam, haloperidol, and prednisolone by rat liver microsomal enzymes were studied in vitro. Dimephosphone, xydiphone, and ionol exhibited similar inductive effects on C-hydroxylation reactions in the CYP P-450 system during treatment with phenobarbital. Xydiphone and ionol in a dose of 1 mmol/kg canceled phenobarbital-induced increase in P-450 cytochrome content in rat liver. Sex-dependent cytochromes P-450 are involved in the prednisolone and haloperidol C-hydroxylation reactions in rats. |
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ISSN: | 0007-4888 1573-8221 |
DOI: | 10.1007/s10517-005-0051-6 |