Partial HIF-1alpha deficiency impairs pulmonary arterial myocyte electrophysiological responses to hypoxia

Chronic hypoxia depolarizes and reduces K+ current in pulmonary arterial smooth muscle cells (PASMCs). Our laboratory previously demonstrated that hypoxia-inducible factor-1 (HIF-1) contributed to the development of hypoxic pulmonary hypertension.

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Bibliographic Details
Published inAmerican journal of physiology. Lung cellular and molecular physiology Vol. 25; no. 1; p. L202
Main Authors Shimoda, Larissa A, Manalo, Dominador J, Sham, James S K, Semenza, Gregg L, Sylvester, J T
Format Journal Article
LanguageEnglish
Published Bethesda American Physiological Society 01.07.2001
Subjects
Blood vessels
Cells
Cellular biology
Lungs
Muscular system
Oxygen
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Summary:Chronic hypoxia depolarizes and reduces K+ current in pulmonary arterial smooth muscle cells (PASMCs). Our laboratory previously demonstrated that hypoxia-inducible factor-1 (HIF-1) contributed to the development of hypoxic pulmonary hypertension.
ISSN:1040-0605
1522-1504