Induction of MMP-9 in normal human bronchial epithelial cells by TNF-alpha via NF-kappaB-mediated pathway

In this study, we determined whether the proinflammatory cytokines tumor necrosis factor (TNF)-alpha and interleukin-1beta contribute to the regulation of matrix metalloproteinase (MMP)-9 in human bronchial epithelial cells and whether the induction of MMP-9 is regualted by the transcription factor...

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Bibliographic Details
Published inAmerican journal of physiology. Lung cellular and molecular physiology Vol. 25; no. 6; p. L1444
Main Authors Hozumi, Atsuko, Nishimura, Yoshihiro, Nishiuma, Teruaki, Kotani, Yoshikazu, Yokoyama, Mitsuhiro
Format Journal Article
LanguageEnglish
Published Bethesda American Physiological Society 01.12.2001
Subjects
Cells
Cytokines
Respiratory system
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Summary:In this study, we determined whether the proinflammatory cytokines tumor necrosis factor (TNF)-alpha and interleukin-1beta contribute to the regulation of matrix metalloproteinase (MMP)-9 in human bronchial epithelial cells and whether the induction of MMP-9 is regualted by the transcription factor nuclear factor (NF0-KB.
ISSN:1040-0605
1522-1504