NADPH oxidase promotes NF-kappaB activation and proliferation in human airway smooth muscle

Evidence is rapidly accumulating that low-activity-reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidases homologous to that in phagocytic cells generate reactive oxygen species as singaling intermediates in both endothelium and vascular smooth muscle. We therefore explored the possibi...

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Bibliographic Details
Published inAmerican journal of physiology. Lung cellular and molecular physiology Vol. 26; no. 4; p. L782
Main Authors Brar, Sukhdev S, Kennedy, Thomas P, Sturrock, Anne B, Huecksteadt, Thomas P
Format Journal Article
LanguageEnglish
Published Bethesda American Physiological Society 01.04.2002
Subjects
Cells
Muscular system
Respiratory system
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Summary:Evidence is rapidly accumulating that low-activity-reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidases homologous to that in phagocytic cells generate reactive oxygen species as singaling intermediates in both endothelium and vascular smooth muscle. We therefore explored the possibility of such an oxidase regulating growth of airway smooth muscle (AWSM).
ISSN:1040-0605
1522-1504