Directionality of glioblastoma invasion in a 3d in vitro experiment

Glioblastoma is the most malignant form of brain cancer. It is extremely invasive; the mechanisms that govern invasion are not well understood. To better understand the process of invasion, we conducted an in vitro experiment in which a 3d tumour spheroid is implanted into a collagen gel. The paths...

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Bibliographic Details
Published inarXiv.org
Main Authors Stein, A M, Vader, D A, Deisboeck, T S, Chiocca, E A, Sander, L M, Weitz, D A
Format Paper
LanguageEnglish
Published Ithaca Cornell University Library, arXiv.org 17.10.2006
Subjects
Bias
Brain
Collagen
Radial velocity
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Summary:Glioblastoma is the most malignant form of brain cancer. It is extremely invasive; the mechanisms that govern invasion are not well understood. To better understand the process of invasion, we conducted an in vitro experiment in which a 3d tumour spheroid is implanted into a collagen gel. The paths of individual invasive cells were tracked. These cells were modeled as radially biased, persistent random walkers. The radial velocity bias was found to be 20 microns/hr on day one, but decayed significantly by day two. The cause of this bias is thought to be due to chemotactic factors and contact guidance along collagen fibers.
ISSN:2331-8422