Microarray Data Management. An Enterprise Information Approach: Implementations and Challenges

The extraction of information form high-throughput experiments is a key aspect of modern biology. Early in the development of microarray technology, researchers recognized that the size of the datasets and the limitations of both computational and visualization techniques restricted their ability to...

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Bibliographic Details
Published inarXiv.org
Main Authors Valdivia-Granda, Willy, Dwan, Christopher
Format Paper
LanguageEnglish
Published Ithaca Cornell University Library, arXiv.org 03.05.2006
Subjects
Data base management systems
Data management
Data storage
Data structures
Datasets
Experiments
Federations
Information management
New technology
Researchers
Standardization
Visualization
Warehouses
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Summary:The extraction of information form high-throughput experiments is a key aspect of modern biology. Early in the development of microarray technology, researchers recognized that the size of the datasets and the limitations of both computational and visualization techniques restricted their ability to find the biological meaning hidden in the data. In addition, most researchers wanted to make their datasets accessible to others. This resulted in the development of new and advanced data storage, analysis, and visualization tools enabling the cross-platform validation of the experiments and the identification of previously undetected patterns. In order to reap the benefits of this microarray data, researchers have needed to implement database management systems providing integration of different experiments and data types. Moreover, it was necessary to standardize the basic data structure and experimental techniques for the standardization of microarray platforms. In this chapter, we introduce the reader to the major concepts related to the use of controlled vocabularies (ontologies), the definition of Minimum Information About a Microarray Experiment (MIAME) and provide an overview of different microarray data management strategies in use today. We summarize the main characteristics of microarray data storage and sharing strategies including warehouses, datamarts, and federations. The fundamental challenges involved in the distribution, and retrieval of microarray data are presented, along with an overview of some emerging technologies.
ISSN:2331-8422