Comparative analysis of protein structure using multiscale additive functionals

This work reports a new methodology aimed at describing characteristics of protein structural shapes, and suggests a framework in which to resolve or classify automatically such structures into known families. This new approach to protein structure characterization is based on elements of integral g...

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Bibliographic Details
Published inarXiv.org
Main Authors Marconi Soares Barbosa, Rinaldo Wander Montalvao, Blundell, Tom, Luciano da Fontoura Costa
Format Paper
LanguageEnglish
Published Ithaca Cornell University Library, arXiv.org 14.01.2007
Subjects
Multiscale analysis
Proteins
Representations
Structural analysis
Structural shapes
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Summary:This work reports a new methodology aimed at describing characteristics of protein structural shapes, and suggests a framework in which to resolve or classify automatically such structures into known families. This new approach to protein structure characterization is based on elements of integral geometry using biologically relevant measurements of shape and considering them on a multi-scale representation which align the proposed methodology to the recently reported "tube picture" of a protein structure as a minimal representation model. The method has been applied with good results to a subset of protein structures known to be especially challenging to revert into families, confirming the potential of the proposed method for accurate structure classification.
ISSN:2331-8422