Simulation of cellular irradiation with the CENBG microbeam line using GEANT4

Light-ion microbeams provide a unique opportunity to irradiate biological samples at the cellular level and to investigate radiobiological effects at low doses of high LET ionising radiation. Since 1998 a single-ion irradiation facility has been developed on the focused horizontal microbeam line of...

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Published inarXiv.org
Main Authors Incerti, S, Barberet, Ph, Villeneuve, R, Aguer, P, Gontier, E, Michelet-Habchi, C, Moretto, Ph, Nguyen, D T, Pouthier, T, Smith, R W
Format Paper
LanguageEnglish
Published Ithaca Cornell University Library, arXiv.org 25.10.2003
Subjects
Alpha particles
Alpha rays
Biological properties
Ion irradiation
Ionizing radiation
Microbeams
Spatial resolution
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Summary:Light-ion microbeams provide a unique opportunity to irradiate biological samples at the cellular level and to investigate radiobiological effects at low doses of high LET ionising radiation. Since 1998 a single-ion irradiation facility has been developed on the focused horizontal microbeam line of the CENBG 3.5 MV Van de Graaff accelerator. This setup delivers in air single protons and alpha particles of a few MeV onto cultured cells, with a spatial resolution of a few microns, allowing subcellular targeting. In this paper, we present results from the use of the GEANT4 toolkit to simulate cellular irradiation with the CENBG microbeam line, from the entrance to the microprobe up to the cellular medium.
ISSN:2331-8422
DOI:10.48550/arxiv.0310130