Cellular Uptake and Biocompatibility of Bismuth Ferrite Harmonic Advanced Nanoparticles
Bismuth Ferrite (BFO) nanoparticles (BFO-NP) display interesting optical (nonlinear response) and magnetic properties which make them amenable for bio-oriented applications as intra- and extra membrane contrast agents. Due to the relatively recent availability of this material in well dispersed nano...
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Published in | arXiv.org |
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Main Authors | , , , , , , , , , , , , , , , , |
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Cornell University Library, arXiv.org
08.10.2014
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Abstract | Bismuth Ferrite (BFO) nanoparticles (BFO-NP) display interesting optical (nonlinear response) and magnetic properties which make them amenable for bio-oriented applications as intra- and extra membrane contrast agents. Due to the relatively recent availability of this material in well dispersed nanometric form, its biocompatibility was not known to date. In this study, we present a thorough assessment of the effects of in vitro exposure of human adenocarcinoma (A549), lung squamous carcinoma (NCI-H520), and acute monocytic leukemia (THP-1) cell lines to uncoated and poly(ethylene glycol)-coated BFO-NP in the form of cytotoxicity, haemolytic response and biocompatibility. Our results support the attractiveness of the functional-BFO towards biomedical applications focused on advanced diagnostic imaging. |
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AbstractList | Bismuth Ferrite (BFO) nanoparticles (BFO-NP) display interesting optical (nonlinear response) and magnetic properties which make them amenable for bio-oriented applications as intra- and extra membrane contrast agents. Due to the relatively recent availability of this material in well dispersed nanometric form, its biocompatibility was not known to date. In this study, we present a thorough assessment of the effects of in vitro exposure of human adenocarcinoma (A549), lung squamous carcinoma (NCI-H520), and acute monocytic leukemia (THP-1) cell lines to uncoated and poly(ethylene glycol)-coated BFO-NP in the form of cytotoxicity, haemolytic response and biocompatibility. Our results support the attractiveness of the functional-BFO towards biomedical applications focused on advanced diagnostic imaging. |
Author | Bonacina, Luigi Wolf, Jean-Pierre Ronan Le Dantec Prina-Melloc, Adriele Staedler, Davide Rogov, Andrii Jüstel, Thomas Hwu, Stéphanie Gerber-Lemaire, Sandrine Rytz, Daniel Magouroux, Thibaud Mohamed, Bashir M Volkov, Yuri Mugnier, Yannick Schwung, Sebastian Passemard, Solène Ciaran Manus Maguire |
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SubjectTerms | Biocompatibility Biomedical materials Bismuth ferrite Contrast agents Diagnostic software Diagnostic systems Magnetic properties Nanoparticles Nonlinear response Optical properties Polyethylene glycol Toxicity |
Title | Cellular Uptake and Biocompatibility of Bismuth Ferrite Harmonic Advanced Nanoparticles |
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