Cellular Uptake and Biocompatibility of Bismuth Ferrite Harmonic Advanced Nanoparticles

Bismuth Ferrite (BFO) nanoparticles (BFO-NP) display interesting optical (nonlinear response) and magnetic properties which make them amenable for bio-oriented applications as intra- and extra membrane contrast agents. Due to the relatively recent availability of this material in well dispersed nano...

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Published inarXiv.org
Main Authors Staedler, Davide, Passemard, Solène, Magouroux, Thibaud, Rogov, Andrii, Ciaran Manus Maguire, Mohamed, Bashir M, Schwung, Sebastian, Rytz, Daniel, Jüstel, Thomas, Hwu, Stéphanie, Mugnier, Yannick, Ronan Le Dantec, Volkov, Yuri, Gerber-Lemaire, Sandrine, Prina-Melloc, Adriele, Bonacina, Luigi, Wolf, Jean-Pierre
Format Paper
LanguageEnglish
Published Ithaca Cornell University Library, arXiv.org 08.10.2014
Subjects
Biocompatibility
Biomedical materials
Bismuth ferrite
Contrast agents
Diagnostic software
Diagnostic systems
Magnetic properties
Nanoparticles
Nonlinear response
Optical properties
Polyethylene glycol
Toxicity
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Summary:Bismuth Ferrite (BFO) nanoparticles (BFO-NP) display interesting optical (nonlinear response) and magnetic properties which make them amenable for bio-oriented applications as intra- and extra membrane contrast agents. Due to the relatively recent availability of this material in well dispersed nanometric form, its biocompatibility was not known to date. In this study, we present a thorough assessment of the effects of in vitro exposure of human adenocarcinoma (A549), lung squamous carcinoma (NCI-H520), and acute monocytic leukemia (THP-1) cell lines to uncoated and poly(ethylene glycol)-coated BFO-NP in the form of cytotoxicity, haemolytic response and biocompatibility. Our results support the attractiveness of the functional-BFO towards biomedical applications focused on advanced diagnostic imaging.
ISSN:2331-8422