The competitive nature of STAT complex formation drives phenotype switching of T cells

• Published in: arXiv.org
• Main Authors: Sadreev, Ildar I, Chen, Michael Z Q, Umezawa, Yoshinori, Biktashev, Vadim N, Kemper, Claudia, Salakhieva, Diana V, Welsh, Gavin I, Kotov, Nikolay V
• Format: Paper
• Language: English
• Published: Ithaca Cornell University Library, arXiv.org 19.01.2017
• Subjects: Complex formation; Cytokines; Dimers; Genotype & phenotype; Human behavior; Lymphocytes; Plastic properties; Proteins; Signaling; Switching; Transducers
• ISSN: 2331-8422

Signal transducers and activators of transcription (STATs) are key molecular determinants of T cell fate and effector function. A number of inflammatory diseases are characterized by an altered balance of T cell phenotypes and cytokine secretion. STATs, therefore, represent viable therapeutic targets in numerous pathologies. However, the underlying mechanisms of how the same STAT proteins regulate both the development of different T cell phenotypes and their plasticity during changes in extracellular conditions remain unclear. In this study, we investigated the STAT mediated regulation of T cell phenotype formation and plasticity using mathematical modeling and experimental data for intracellular STAT signaling proteins. The close fit of our model predictions to the experimental data for IFN-{\gamma} to IL-10 switching allows us to propose a potential mechanism for T cell switching that regulates human Th1/Tr1 responses. According to this mechanism, T cell phenotype switching is due to the relative redistribution of STAT dimer complexes caused by the extracellular cytokine-dependent STAT competition effects. The proposed model is applicable to a number of STAT signaling circuits.