Enterococcus faecalis Modulates Immune Activation And Slows Healing During Wound Infection

• Published in: bioRxiv
• Main Authors: Kelvin Kian Long Chong, Wei Hong Tay, Janela, Baptiste, Mei Hui Adeline Yong, Tze Horng Liew, Madden, Leigh, Keogh, Damien, Barkham, Timothy, Ginhoux, Florent, Becker, David Laurence, Kline, Kimberly A
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 07.04.2017
• Subjects: Bacterial proteins; Colonization; Cytokines; Fitness; Immune clearance; Immune response; Immunomodulation; Infections; Inflammation; Inoculum; Wound healing; Wound infection

Enterococcus faecalis is one of most frequently isolated bacterial species in wounds yet little is known about its pathogenic mechanisms in this setting. Here, we used a mouse wound excisional model to characterize the infection dynamics of E. faecalis and show that infected wounds result in two dif...