Communication from learned to innate olfactory processing centers is required for memory retrieval in Drosophila

Animals can show either learned or innate behavioral responses to a given stimulus. How these circuits interact to produce an appropriate behavioral response is unknown. In the Drosophila olfactory system, the lateral horn (LH) and the mushroom body (MB) are thought to mediate innate and learned olf...

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Published inbioRxiv
Main Authors Michael-John Dolan, Belliart-Guerin, Ghislain, Bates, Alexander S, Aso, Yoshinori, Frechter, Shahar, Roberts, Ruairi J V, Schlegel, Philipp, Wong, Allan, Hammad, Adnan, Bock, Davi, Rubin, Gerald M, Preat, Thomas, Pierre-Yves Placais, Gregory S X E Jefferis
Format Paper
LanguageEnglish
Published Cold Spring Harbor Cold Spring Harbor Laboratory Press 29.08.2017
Subjects
Behavior
Chemical communication
Information processing
Insects
Learning
Neural networks
Olfactory neurons
Olfactory pathways
Olfactory system
Smell
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Summary:Animals can show either learned or innate behavioral responses to a given stimulus. How these circuits interact to produce an appropriate behavioral response is unknown. In the Drosophila olfactory system, the lateral horn (LH) and the mushroom body (MB) are thought to mediate innate and learned olfactory behavior respectively, although the function of the LH has not been directly tested. Here we identify two LH cell-types (PD2a1/b1) that receive input from an MB output neuron required for recall of aversive olfactory memories. In contrast to the model above we find that PD2a1/b1 are required for aversive memory retrieval. PD2a1/b1 activity is modulated by training, indicating that memory information is passed to the innate olfactory processing centre. We map the connectivity of PD2a1/b1 to other olfactory neurons with connectomic data. This provides a circuit mechanism by which learned and unlearned olfactory information can interact to produce appropriate behavior.
DOI:10.1101/167312