Development of Liposome Formulations of Tamoxifen and Assessment of Caco-2 Cell Transportation Properties

[...]surgical procedures come to mind as the most effective method (Alison, 2001) followed by chemotherapy and/or radiotherapy which usually leads unselective damages on healthy tissues (Hull et al., 2014). Another treatment approach has been hormonal therapy for estrogen receptor (ER) and progester...

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Bibliographic Details
Published inFABAD journal of pharmaceutical sciences Vol. 43; no. 1; pp. 1 - 6
Main Authors Ağardan, N Başaran Mutlu, Değim, Zelihagül, Yilmaz, Şükran
Format Journal Article
LanguageEnglish
Published Ankara Hacettepe University Faculty of Medicine 01.01.2018
Subjects
Bioavailability
Breast cancer
Cancer therapies
Drug delivery systems
FDA approval
Health risk assessment
Lipids
Medical research
Metastasis
Nanoparticles
Nanotechnology
Permeability
Pharmaceuticals
Trends
Womens health
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Summary:[...]surgical procedures come to mind as the most effective method (Alison, 2001) followed by chemotherapy and/or radiotherapy which usually leads unselective damages on healthy tissues (Hull et al., 2014). Another treatment approach has been hormonal therapy for estrogen receptor (ER) and progesterone receptorpositive breast cancers. Since %75 of breast cancers are ER positive (ER +), hormonal therapy is promising as an effective and quite well-tolerated treatment (Barse, 2000). According to this equation, dQ/dt refers permeability rate, A (cm2) refers membrane diffusion area and C0 (pg/mL) refers the initial concentration in the donor compartment. According to MTT test results, it was decided to use tamoxifen in 120 pg/mL, DM-ß-CD in %0.15, NaTC in 0.005 mM concentrations with the cell viability results of 78.4%, 66,7, 68.4%, respectively.
ISSN:1300-4182