Gating of O(2)-Sensitive K(Plus) Channels of Arterial Chemoreceptor Cells and Kinetic Modifications Induced by Low P(O)(2)

The major gating properties of O2-sensitive potassiumplus channels in excised membrane patches can be explained by a minimal kinetic scheme that includes several closed states, an open state and two inactivated states. Results from depolarization help to understand the molecular mechanisms underlyin...

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Bibliographic Details
Published inThe Journal of general physiology Vol. 100; no. 3; p. 427
Main Authors Ganfornina, Maria Dolores, Lopez-Barneo, Jose
Format Journal Article
LanguageEnglish
Published New York Rockefeller University Press 01.09.1992
Subjects
Biochemistry
Minerals
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Summary:The major gating properties of O2-sensitive potassiumplus channels in excised membrane patches can be explained by a minimal kinetic scheme that includes several closed states, an open state and two inactivated states. Results from depolarization help to understand the molecular mechanisms underlying the enhancement of the excitability of glomus cells in response to hypoxia.
ISSN:0022-1295
1540-7748