MINIREVIEW What MAN1 does to the Smads

The inner nuclear membrane protein MAN1 has been identified as an important factor in transforming growth factor Beta/bone morphogenic protein (TGFBeta/BMP) signaling. Loss of MAN1 results in three autosomal dominant diseases in humans; all three characterized by increased bone density. Xenopus embr...

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Bibliographic Details
Published inThe FEBS journal Vol. 274; no. 6; p. 1374
Main Author Bengtsson, Luiza
Format Journal Article
LanguageEnglish
Published Oxford Blackwell Publishing Ltd 01.03.2007
Subjects
Biochemistry
Embryos
Proteins
Signal transduction
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Summary:The inner nuclear membrane protein MAN1 has been identified as an important factor in transforming growth factor Beta/bone morphogenic protein (TGFBeta/BMP) signaling. Loss of MAN1 results in three autosomal dominant diseases in humans; all three characterized by increased bone density. Xenopus embryos lacking MAN1 develop severe morphological defects. Both in humans and in Xenopus embryos the defects originate from deregulation of TGFBeta/BMP signaling. Several independent studies have shown that MAN1 is antagonizing TGFBeta/BMP signaling through binding to regulatory Smads. Here, recent progress in understanding MAN1 functions is summarized and a model for MAN1-dependent regulation of TGFBeta/BMP signaling is proposed. [PUBLICATION ABSTRACT]
ISSN:1742-464X
1742-4658
DOI:10.1111/j.1742-4658.2007.05696.x