Worse Prognosis in Lung Cancer Patients can be Predicted by ^sup 99^Tc^sup m^N-NOET Dual-phase SPECT of More Accumulation

• Published in: The Journal of nuclear medicine (1978) Vol. 58; p. 88
• Main Authors: Liu, Haiyan, Wu, Zhifang, Yang, Suyun, Liu, Jianzhong, Cheng, Yan, Wei, Hua, Hu, Guang, Qin, Lijun, Li, Wanting, Li, Sijin
• Format: Journal Article
• Language: English
• Published: New York Society of Nuclear Medicine 01.05.2017
• Subjects: Accumulation; Age; Cancer; Conflicts of interest; Family planning; Informed consent; Innovations; Lung cancer; Malignancy; Medical innovations; Medical prognosis; Metastases; Oncology; Parameters; Patients; Prognosis; R&D; Rank tests; Regression analysis; Regression models; Research & development; Research projects; Single photon emission computed tomography; Smoking; Survival; Tomography; Youth
• ISSN: 0161-5505; 1535-5667

The authors declare no conflicts of interest. Support This work was also supported in part by Health and Family Planning Commission of Shanxi Province Foundation (2015036) This work was supported in part by a grant from University of science and technology innovation projects in Shanxi Province (20141101) This work was supported in part by a grant from Youth Innovation Fund of The First Hospital of Shanxi Medical University(YC1424) This work was supported in part by a grant from Youth Innovation Fund of Shanxi Medical University(01201415) This work was supported in part by a grant from Youth of Basic Research Project of Shanxi Province (2012021030-2) Objectives: The aim of this study was to determine the semi-quantitative parameters of 99TcmN-NOET dual-phase SPECT is associated with overall survival (OS) of patients with lung cancer. Methods: The institutional review board approved this study and waived the requirement for obtaining informed consent. Fifty-one patients (37 men, mean age 57 ± 9 years) with primary malignancy of lung underwent CT, early and delay 99TcmN-NOET dual-phase SPECT before operated from Jul, 2007 to Oct, 2007. All patients completed clinical follow-up regarding poor prognosis (recurrence and metastasis, death) for a mean period of 64 ± 38.4 months. Kaplan-Meier analysis with the log-rank test and Cox regression survival analyses were used to assess the association of OS with 99TcmN-NOET dual-phase SPECT semi-quantitative parameters, the early T/N ratio (ER),delayed T/N ratio (DR) and the retention index (RI%). Results: Kaplan-Meier analysis and univariate Cox regression models demonstrated significant associations of OS with age, gender, smoking history, ER and DR. Multivariable Cox regression models showed significant relationship of OS with ER (HR = 6.104, P < 0.001) and DR (HR = 1.985, P < 0.001) after adjusting for age, gender and smoking history, respectively. Conclusion: The more accumulation of 99TcmN-NOET dual-phase SPECT was associated with worse prognosis in patients with lung cancer. In long-term follow-up, the semi quantitative index of 99TcmN-NOET dual-phase SPECT could be proved highly predictive of poor prognosis in patients with lung cancer, and hence deserves further investigation.