3D-SSP analysis revealed dual isotope SPECT of CBF and BZR with high sensitivity semiconductor system equivalent findings to single isotope SPECT with conventional high resolution SPECT system in patients with epilepsy

Objectives: We developed a prototype CdTe SPECT system with 4-Pixel Matched Collimator for brain study. This system provides high energy resolution (6.6%), high sensitivity (220 cps/MBq/head) and high spatial resolution images. The aim of this study is to evaluate dual isotope study of CBF and centr...

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Bibliographic Details
Published inThe Journal of nuclear medicine (1978) Vol. 58; p. 226
Main Authors Shiga, Tohru, Suzuki, Atsuro, Sakurai, Kotarou, Tsugiko, Kurita, Takeuchi, Wataru, Toyonaga, Takuya, Hirata, Kenji, Katoh, Chietsugu, Kobashi, Keiji, Tamaki, Nagara
Format Journal Article
LanguageEnglish
Published New York Society of Nuclear Medicine 01.05.2017
Subjects
Benzodiazepines
Brain
Collimation
Correlation analysis
Correlation coefficient
Correlation coefficients
Energy resolution
Epilepsy
Image acquisition
Injection
Isotopes
Lesions
Medical imaging
Nuclear medicine
Patients
Pixels
Quantitative analysis
Scintillation
Sensitivity
Single photon emission computed tomography
Spatial resolution
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Summary:Objectives: We developed a prototype CdTe SPECT system with 4-Pixel Matched Collimator for brain study. This system provides high energy resolution (6.6%), high sensitivity (220 cps/MBq/head) and high spatial resolution images. The aim of this study is to evaluate dual isotope study of CBF and central benzodiazepine receptor (BZR) images using Tc-99m ECD and I-123 IMZ with the new SPECT system in patients with epilepsy comparing with single isotope study using the conventional scintillation gamma camera. Methods: This study included 13 patients with partial epilepsy. BZR images were acquired at 3 hours after I-123 IMZ injection for 20 minutes. The images of IMZ were acquired with a conventional 3 head scintillation gamma camera. After BZR image acquisition with the conventional camera, Tc-99m ECD was injected and CBF and BZR images were acquired simultaneously 5 minutes after ECD injection with the new SPECT system. CBF images were also acquired with the conventional camera on separate days. The findings were visually and semi-quantitatively analyzed. In semi-quantitative analysis, the maximum Z scores of concordant lesions were compared between the two studies using the Pearson correlation coefficient.The 9mm circular ROI was used and two lesions in each patient were analyzed. A p value < 0.05 was considered as significant. Results: There were 47 abnormal lesions on BZR images and 60 abnormal lesions on CBF images in the single isotope study with the conventional camera. Dual isotope study with the new system showed concordant abnormal findings of 46/47 lesions on BZR and 54/60 lesions on CBF images with the single isotope study with the conventional camera. There was high agreement between the two studies in both BZR and CBF findings (Cohen's kappa values; 0.96 for BZR, 0.78 for CBF). In semi-quantitative analysis, maximum Z scores of dual isotope study with the new system strongly correlated with those of single isotope study with the conventional camera (BZR: r=0.82, p < 0.05, CBF: r=0.87, p < 0.05). Conclusion: Our new SPECT system permits dual-isotope study for pixel-by-pixel analysis of CBF and benzodiazepine receptor information with the same pathophysiological condition in patients with epilepsy.
ISSN:0161-5505
1535-5667