Marrow adipose tissue spectrum in obesity and type 2 diabetes mellitus

Objective To assess the association of bone mass and marrow adipose tissue (MAT) with other fat depots, insulin resistance, bone remodeling markers, adipokines and glucose control in type 2 diabetes and obesity. Design and methods The study groups comprised 24 controls (C), 26 obese (O) and 28 type...

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Published inEuropean journal of endocrinology Vol. 175; no. 1; p. 21
Main Authors de Araújo, Iana M, G Salmon, Carlos E, Nahas, Andressa K, Nogueira-Barbosa, Marcello H, Elias, Jorge, de Paula, Francisco J A
Format Journal Article
LanguageEnglish
Published Bristol Oxford University Press 01.01.2017
Subjects
Adiponectin
Adipose tissue
Bone marrow
Bone mass
Bone mineral density
Bone remodeling
Collagen
Diabetes
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Dual energy X-ray absorptiometry
Glucose
Hemoglobin
Insulin
Insulin resistance
Leptin
Lipids
Magnetic resonance imaging
Magnetic resonance spectroscopy
Obesity
Osteocalcin
Regression analysis
Spine
Vertebrae
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Summary:Objective To assess the association of bone mass and marrow adipose tissue (MAT) with other fat depots, insulin resistance, bone remodeling markers, adipokines and glucose control in type 2 diabetes and obesity. Design and methods The study groups comprised 24 controls (C), 26 obese (O) and 28 type 2 diabetes. Dual-energy X-ray absorptiometry was used to determine bone mineral density (BMD). Blood samples were collected for biochemical measurements. 1H Magnetic resonance spectroscopy was used to assess MAT in the L3 vertebra, and abdominal magnetic resonance imaging was used to assess intrahepatic lipids in visceral (VAT) and subcutaneous adipose tissue. Regression analysis models were used to test the association between parameters. Results At all sites tested, BMD was higher in type 2 diabetes than in O and C subjects. The C group showed lower VAT values than the type 2 diabetes group and lower IHL than the O and type 2 diabetes groups. However, MAT was similar in the 3 groups. Osteocalcin and C-terminal telopeptide of type 1 collagen were lower in type 2 diabetes than those in C and O subjects. Moreover, at all sites, BMD was negatively associated with osteocalcin. No association was observed between MAT and VAT. No relationship was observed among MAT and HOMA-IR, leptin, adiponectin or Pref-1, but MAT was positively associated with glycated hemoglobin. Conclusions MAT is not a niche for fat accumulation under conditions of energy surplus and type 2 diabetes, also is not associated with VAT or insulin resistance. MAT is associated with glycated hemoglobin.
ISSN:0804-4643
1479-683X