Antitumor Effect of Dihydroartemisinin on Hypopharyngeal Cancer in Nude Mice with Transplanted Tumor

Objective To investigate the effect of different concentrations of dihydroartemisinin (DHA)on human hypopharyngeal cancer Fadu cells in nude mice. Methods Clonogenic assay was applied to determine whether DHA (10, 20 and 40μmol/L) for 24h affected long-term colony formation. Nude mice with xenograft...

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Published inZhongliu fangzhi yanjiu Vol. 44; no. 10; p. 647
Main Authors Shi, Xinli, Li, Shenghao, Bai, Jing, Wang, Zeming, Zhang, Tianmin, Li, Luya, Li, Guangxing, Li, Xiaoming
Format Journal Article
LanguageChinese
Published Tianjin China Anti-Cancer Association 01.10.2017
Subjects
Anticancer properties
Antitumor activity
Biocompatibility
Cancer
Chemotherapy
Cisplatin
Dihydroartemisinin
Kidneys
Liver
Mice
Spleen
Throat cancer
Toxicity
Tumors
Xenografts
Xenotransplantation
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Summary:Objective To investigate the effect of different concentrations of dihydroartemisinin (DHA)on human hypopharyngeal cancer Fadu cells in nude mice. Methods Clonogenic assay was applied to determine whether DHA (10, 20 and 40μmol/L) for 24h affected long-term colony formation. Nude mice with xenograft tumor model bearing Fadu cells were intraperitoneally injected into low, medium and high concentrations of DHA as DHA groups, while intraperitoneal injection of cisplatin as the chemotherapy group. The volume of transplanted tumor was measured. After three weeks, the xenograft tumors were removed and weighted, then, the inhibitory rates were determined. The potential toxicity was determined through the weight changes of mice, liver, spleen and kidney. Results (1) DHA inhibited the growth of Fadu cells in vitro. (2) The inhibitory rates of low- (25mg/kg), medium- (50mg/kg) and high- (100mg/kg) dose DHA groups were 39.74 %, 60.52 % and 78.70%, while, 79.22% in cisplatin group. (3) DHA had no effect on body and kidne
ISSN:1000-8578