Testosterone prevents the heat shock-induced overactivation of glycogen sythase kinase-3beta but not of cyclin-dependent kinase 5 and c-Jun NH2-terminal kinase and concomitantly

We have shown previously that glycogen synthase kinase-3beta (GSK-3beta), cyclin-dependent kinase 5, and c-Jun NH2-terminal kinase become overactivated and hyperphosphorylate tau in heat-shocked female rats. This hyperphosphorylation of tau is estrogen-independent, prevented by androgens, and simila...

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Bibliographic Details
Published inProceedings of the National Academy of Sciences - PNAS Vol. 99; no. 3; p. 1140
Main Authors Papasozomenos, Sozos Ch, Shanavas, Alikunju
Format Journal Article
LanguageEnglish
Published Washington National Academy of Sciences 05.02.2002
Subjects
Alzheimer's disease
Androgens
Biology
Heat
Rodents
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Summary:We have shown previously that glycogen synthase kinase-3beta (GSK-3beta), cyclin-dependent kinase 5, and c-Jun NH2-terminal kinase become overactivated and hyperphosphorylate tau in heat-shocked female rats. This hyperphosphorylation of tau is estrogen-independent, prevented by androgens, and similar to Alzheimer's disease.
ISSN:0027-8424
1091-6490