Ethionaminde activation and sensitivity in multidrug-resistant Mycobacterium tuberculosis

Ethionamide (ETA) is an important component of second-line therapy for the treatment of multidrug-resistant tuberculosis. Synthesis of radiolabeled ETA and an examination of drug metabolites formed by whole cells of Mycobacterium tuberculosis (MTb) have allowed us to demonstrate that ETA is activate...

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Published inProceedings of the National Academy of Sciences - PNAS Vol. 97; no. 17; p. 9677
Main Authors DeBarber, Andrea E, Mdluli, Khisimuzi, Bosman, Marlein, Linda-Gail Bekker, Barry, Clifton E
Format Journal Article
LanguageEnglish
Published Washington National Academy of Sciences 15.08.2000
Subjects
Drug resistance
Microbiology
Tuberculosis
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Summary:Ethionamide (ETA) is an important component of second-line therapy for the treatment of multidrug-resistant tuberculosis. Synthesis of radiolabeled ETA and an examination of drug metabolites formed by whole cells of Mycobacterium tuberculosis (MTb) have allowed us to demonstrate that ETA is activated by Soxidation before interacting with its cellular target.
ISSN:0027-8424
1091-6490