Agonists and antagonists bind to different domains of the cloned (kappa) opioid receptor

Opioids exert their diverse physiological effects through specific membrane-bound receptors. The ability to dissociate agonist- and antagonist-binding sites on these receptors will facilitate the development of more specific kappa agonists that could have analgesic properties devoid of side effects.

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Bibliographic Details
Published inProceedings of the National Academy of Sciences - PNAS Vol. 91; no. 17; p. 8042
Main Authors Kong, Haeyoung, Raynor, Karen, Yano, Hideki, Takeda, Jun
Format Journal Article
LanguageEnglish
Published Washington National Academy of Sciences 16.08.1994
Subjects
Analgesics
Biochemistry
Narcotics
Pharmacology
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Summary:Opioids exert their diverse physiological effects through specific membrane-bound receptors. The ability to dissociate agonist- and antagonist-binding sites on these receptors will facilitate the development of more specific kappa agonists that could have analgesic properties devoid of side effects.
ISSN:0027-8424
1091-6490