Therapeutic effects of intraoprative placement of chemotherapy pump and postoperative local infusion of chemotherapeutic drug for breast cancer

• Published in: Jie fang jun yi xue za zhi Vol. 36; no. 10; p. 1098
• Main Authors: QIN, Rong, Yong-dong, PU, YANG, Bo, Jian-miao HE, Li-guo, DONG, Zhi-yu, CAO, LV, Gang, LIU, Wei-ping, You-jun, WU
• Format: Journal Article
• Language: Chinese
• Published: Beijing People's Military Medical Press 01.01.2011
• Subjects: Biopsy; Breast cancer; Cancer therapies; Chemotherapy; Drug dosages; Surgery
• ISSN: 0577-7402

Objective To observe the effects of postoperative adjuvant local chemotherapy on the prognosis of the patients with breart cancer,and explore the skill of intraoperative placement of a catheter for postoperative chemotherapy duning the operation.Methods Of 102 patients with breast cancer in stage Ⅱ to Ⅲ,23 were assigned to control group and 79 to catheter and pump-placement group.Quadrantectomy plus axillary lymph node dissection or modified radical mastectomy was performed in both groups,followed by the insertion of a catheter for pumping of chemotherapeutic drug in pump-placement group.The catheter was inserted into axillary artery through the lateral thoracic artery or subscapular artery,connecting with a chemotherapy pump for instillation of chemotherapeutic drug and it was fixed on the skin for local adjuvant chemotherapy thereafter.The catheter was washed with heparin once a week to prevent occlusion.10-14 days after surgery,patients in pump-placement group underwent local chemotherapy with 5-FU at a do