Effects of +G_z exposure on gallbladder emptying function,cholecystokinin,and somatostatin in rabbits with high cholesterol diets

• Published in: Jie fang jun yi xue za zhi Vol. 36; no. 12; p. 1298
• Main Authors: Guo-feng, XIAO, Hong-yi, ZHANG, Xiao-jun, HE, ZHAO, Gang, YA-lin, KONG, LIU, Yang
• Format: Journal Article
• Language: Chinese
• Published: Beijing People's Military Medical Press 01.01.2011
• Subjects: Cholesterol; Gallbladder
• ISSN: 0577-7402

Objective The present study explores the effects of +Gz exposure on the gallbladder emptying function,cholecystokinin(CCK),and somatostatin(SS) in rabbits with high cholesterol diets and investigates its mechanism in the occurrence of cholecystolithiasis.Methods Twenty-four male New Zealand rabbits were randomly divided into the high cholesterol diet(control group,n=8) and high cholesterol diet plus +Gz exposure groups.The latter was divided into the four-and six-week +Gz exposure groups(n=8) based on the exposure time.Radioimmunoassay was used to determine the CCK and SS contents of the gallbladder at the end of the experiment in the fourth and sixth weeks and to calculate the gallbladder volume and maximum emptying ratio.A microcomputer biodynamic pressure monitor was used to record the hydrostatic pressure in the gallbladder to measure its capacity.Moreover,the bile properties and formation of concretion were observed with the naked eye,and polarized light microscopy was used to observe cholesterin crystal