Effects of resuscitation with three kinds of fluid on liver oxygen free radical in rats with severe hemorrhagic shock

Objective 　To explore effects of resuscitation with different kinds of fluid on liver oxygen free radical in rats with severe hemorrhagic shock. Methods 　Sixty SD Rats were randomly divided into 5 groups (n=12): control group (C), shock alone group (SA), lactated Ringer's solution (LR)-treatmen...

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Published inJie fang jun yi xue za zhi Vol. 37; no. 12; p. 1111
Main Authors Hua-mei, LU, Li-juan, WEI, Mu-qiang, YANG, Zhi-long GENG, ZHAO, Feng
Format Journal Article
LanguageChinese
Published Beijing People's Military Medical Press 01.01.2012
Subjects
Cytokines
Free radicals
Liver
Rodents
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Summary:Objective 　To explore effects of resuscitation with different kinds of fluid on liver oxygen free radical in rats with severe hemorrhagic shock. Methods 　Sixty SD Rats were randomly divided into 5 groups (n=12): control group (C), shock alone group (SA), lactated Ringer's solution (LR)-treatment group, hydroxyethyl starch (HES)-treatment group, 7.2% hypertonic saline-6% HES (HSH)-treated group. According to Wigger's method, the rat model of severe hemorrhagic shock was reproduced. The mean arterial pressure (MAP) was monitored in all the 5 groups. The ALT and AST level in venous blood were determined before shock (Tb), 1h after shock (Ts) and 4h after resuscitation (Td) respectively. In SA group, the rats were sacrificed and the livers were collected at Ts. The rats were resuscitated with LR (3 times the volume of shed blood), HES (1 time the volume of shed blood) and HSH (6ml/kg) in LR, HES and HSH group respectively. The rats in groups C, LR, HES and HSH were sacrificed at Td to obtain the liver tissues. Th
ISSN:0577-7402