Meta-analysis of the relationship of arterial oxygen saturation and acute mountain sickness

• Published in: Jie fang jun yi xue za zhi Vol. 38; no. 11; p. 940
• Main Authors: Hai-yan, YOU, Xiao-xiao, LI, Zhao-hui, HUANG, Yu-qi, GAO
• Format: Journal Article
• Language: Chinese
• Published: Beijing People's Military Medical Press 01.01.2013
• Subjects: Altitude; Meta-analysis; Risk factors
• ISSN: 0577-7402
• DOI: 10.11855/j.issn.0577-7402.2013.11.016

Objective　To explore the relationship between the arterial oxygen saturation (SaO2) as a susceptibility risk factor for acute mountain sickness (AMS) in healthy people entering a high altitude area abruptly. Methods　A search in Medline, PubMed, Springer, Elsevier and LWW databases was done to collect the reports concerning SaO2 as a susceptibility risk factor for AMS from 2000 to 2010 published in literature abroad, and meta-analysis was performed with RevMan 5.0 software. Results　Nine papers concerning the relationship of AMS and SaO2 were retrieved. The heterogeneity test indicated that the nine studies were consistent statistically (Q=12.98, df=10, P>0.05), the data from these nine studies could be analyzed by fixed effect model. After combination of the data, those of 246 subjects with AMS and 557 subjects without AMS were collected. Test of overall effect by fixed effect model showed that the SaO2 was significantly lower in AMS group than in non-AMS group (weighted mean difference was 4.04, 95%CI was 3.3