Colloid Carcinoma of the Uterine Cervix and Its Immunohistochemical Analysis: A Case Report

Colloid carcinoma, which is a very rare tumor of the uterine cervix, is composed of an excessive amount of mucus and a relative paucity of tumoral glandular cells within them. Herein, we report a rare case of colloid carcinoma of the cervix with adenocarcinoma in situ (AIS), intestinal and usual typ...

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Bibliographic Details
Published inJournal of pathology and translational medicine Vol. 52; no. 1; pp. 56 - 60
Main Authors Koc, Nermin, Arinkan, Sevcan Arzu, Ozbay, Nurver Ozel, Selcuk, Selcuk
Format Journal Article
LanguageEnglish
Published Seoul Korean Society of Pathologists, Korean Society for Cytopathology 01.01.2018
Subjects
Case reports
Classification
Human papillomavirus
Lymphatic system
Metastasis
Morphology
Stains & staining
Uterine cancer
United States > US
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Summary:Colloid carcinoma, which is a very rare tumor of the uterine cervix, is composed of an excessive amount of mucus and a relative paucity of tumoral glandular cells within them. Herein, we report a rare case of colloid carcinoma of the cervix with adenocarcinoma in situ (AIS), intestinal and usual types, and endocervical adenocarcinoma (usual type) components. We also discuss the morphological and immunohistochemical characteristics of this tumor. A 51-year-old woman was referred to our outpatient clinic with the symptom of genital bleeding lasting for 5 months. She had a cervix surrounded by an irregular tumor with a diameter of 5 cm. The colloid carcinoma cells were positive for MUC2, MUC5AC, and cytokeratin (CK) 7, focal positive for CDX2, and negative for MUC6 and CK20. Also, the intestinal type AIS showed a similar staining pattern. Colloid carcinoma cells producing mucin showed an intestinal phenotype and AIS. The intestinal type can be considered as a precursor lesion of colloid carcinoma.
ISSN:2383-7837
2383-7845
DOI:10.4132/jplm.2017.04.08