Gestational tissue inflammatory biomarkers at term labor: Aￂ systematic review of literature

Parturition at term is characterized by inflammatory overload in both feto-maternal tissues. Despite the large number of individual studies on changes in inflammatory biomarkers linked to labor, a comprehensive profile of them in each of the uterine compartments is not available to better understand...

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Published inAmerican journal of reproductive immunology (1989) Vol. 79; no. 2
Main Authors Hadley, Emily E, Richardson, Lauren S, Torloni, Maria R, Menon, Ramkumar
Format Journal Article
LanguageEnglish
Published New Haven Wiley Subscription Services, Inc 01.02.2018
Subjects
Amnion
Biomarkers
Chorion
Cyclooxygenase-2
Decidua
Inflammation
Interleukin 1
Interleukin 6
Interleukin 8
mRNA
Myometrium
Parturition
Placenta
Reviews
Systematic review
Tumor necrosis factor
Uterus
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Summary:Parturition at term is characterized by inflammatory overload in both feto-maternal tissues. Despite the large number of individual studies on changes in inflammatory biomarkers linked to labor, a comprehensive profile of them in each of the uterine compartments is not available to better understand their mechanistic contributions to labor. This systematic review investigated the pro- and anti-inflammatory biomarkers reported in intra-uterine tissues (amnion, chorion, decidua, placenta, and myometrium) at term labor. We conducted a systematic review of studies on pro- and anti-inflammatory biomarkers (mRNA and/or protein) reported in feto-maternal tissues during normal human term labor, published in English (1980-2016), in 3 electronic data bases. From a total of 3712 citations, 172 were included for final review. Each tissue expresses a unique set of biomarkers at the time of term labor, but there is significant overlap between tissues. All tissues had IL-6, IL-8, IL-1[beta], COX-2, PGE-2, TNF-[alpha], and hCAP18 in common at term labor. Common and unique inflammatory biomarkers are expressed in various feto-maternal compartments at term labor. Increase in pro-inflammatory markers in all gestational tissue signifies their harmonious functional role in promoting labor. Anti-inflammatory markers at term labor are hardly reported.
ISSN:1046-7408
1600-0897
DOI:10.1111/aji.12776