Primary Cutaneous CD30 +Anaplastic Large Cell Lymphoma; Report of a single large scalp nodule

Polymerase chain reaction (PCR) study to detect T-cell antigen Beta gene rearrangement showed one band consistent with the expansion of a single clonal T-cell proliferation. Numerous CD30 positive lymphocytes in dermis and subcutaneous fat. (immunoperoxidase stain, 10x) Discussion Primary cutaneous...

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Published inNasza dermatologia online Vol. 5; no. 4; p. 434
Main Authors Parulkar, Isha, Micheals, Jason, Telang, Gladys H
Format Journal Article
LanguageEnglish
Published Slupsk Our Dermatology Online 01.10.2014
Subjects
Antigens
Chemotherapy
Chromosomes
Family medical history
Kinases
Lymphocytes
Lymphoma
Medical prognosis
Neutrophils
Patients
Radiation therapy
Systemic diseases
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Summary:Polymerase chain reaction (PCR) study to detect T-cell antigen Beta gene rearrangement showed one band consistent with the expansion of a single clonal T-cell proliferation. Numerous CD30 positive lymphocytes in dermis and subcutaneous fat. (immunoperoxidase stain, 10x) Discussion Primary cutaneous T-cell lymphomas (CTCL) are a clinically and histologically diverse group of non-Hodgkin lymphomas characterized by the aberrant proliferation of skin-homing T-lymphocytes. Treatment options include surgical excision, localized radiotherapy, topical nitrogen mustard therapy, single and multiagent chemotherapy (most commonly Cyclophosphamide, Doxorubicin, Vincristine, Prednisone or CHOP) [4,5,7]. Massone C, El-Shabrawi-Caelen L, Kerl H, Cerroni L. The morphologic spectrum of primary cutaneous anaplastic large T-cell lymphoma: a histopathologic study on 66 biopsy specimens from 47 patients with report of rare variants.
ISSN:2081-9390
DOI:10.7241/ourd.20144.112