Total Synthesis of Bryostatin8 Using an Organosilane-Based Strategy

Convergent total synthesis of bryostatin8 has been accomplished by an organosilane-based strategy. The Cring is constructed stereoselectively through a geminal bis(silane)-based [1,5]-Brook rearrangement, and the Bring through geminal bis(silane)-based Prins cyclization, thus efficiently joining the...

Full description

Saved in:
Bibliographic Details
Published inAngewandte Chemie International Edition Vol. 57; no. 4; p. 942
Main Authors Zhang, Yuebao, Guo, Qianyou, Sun, Xianwei, Lu, Ji, Cao, Yanjun, Pu, Qiang, Chu, Zhiwen, Gao, Lu, Song, Zhenlei
Format Journal Article
LanguageEnglish
Published Weinheim Wiley Subscription Services, Inc 22.01.2018
EditionInternational ed. in English
Subjects
Synthesis
Online AccessGet full text

Cover

More Information
Summary:Convergent total synthesis of bryostatin8 has been accomplished by an organosilane-based strategy. The Cring is constructed stereoselectively through a geminal bis(silane)-based [1,5]-Brook rearrangement, and the Bring through geminal bis(silane)-based Prins cyclization, thus efficiently joining the northern and southern parts of the molecule.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201711452