Addition of eicosapentaenoic acid to(gamma-linolenic) acid-supplemented diets prevents serum arachidonic acid accumulation in humans

Previous studies reveal that supplementation of human diets with gamma-linolenic acid (GLA) reduces the generation of lipid mediators of inflammation and attenuates clinical symptoms of chronic inflammatory disorders such as rheumatoid arthritis. However, we have shown that supplementation with this...

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Bibliographic Details
Published inThe Journal of nutrition Vol. 130; no. 8; p. 1925
Main Authors Barham, J Brooke, Edens, Michelle B, Fonteh, Alfred N, Johnson, Margaret M
Format Journal Article
LanguageEnglish
Published Bethesda American Institute of Nutrition 01.08.2000
Subjects
Acids
Diet
Metabolism
Nutrition
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Summary:Previous studies reveal that supplementation of human diets with gamma-linolenic acid (GLA) reduces the generation of lipid mediators of inflammation and attenuates clinical symptoms of chronic inflammatory disorders such as rheumatoid arthritis. However, we have shown that supplementation with this same fatty acid also causes a marked increase in serum arachidonate (AA) levels, a potentially harmful side effect.
ISSN:0022-3166
1541-6100