Rationale for Using High-Dose Multiple Dietary Antioxidants as an Adjunct to Radiation Therapy and Chemotherapy1,2

Prasad tackles that dietary antioxidants at high doses include differentiation, proliferation inhibition, and apoptosis, depending on the dose and type of antioxidants, treatment schedule, and type of tumor cells, without producing similar effects on most normal cells in vitro and in vivo. The growt...

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Bibliographic Details
Published inThe Journal of nutrition Vol. 134; no. 11; p. 3182S
Main Author Prasad, Kedar N
Format Journal Article
LanguageEnglish
Published Bethesda American Institute of Nutrition 01.11.2004
Subjects
Antioxidants
Cancer
Chemotherapy
Diet
Disease management
Radiation
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Summary:Prasad tackles that dietary antioxidants at high doses include differentiation, proliferation inhibition, and apoptosis, depending on the dose and type of antioxidants, treatment schedule, and type of tumor cells, without producing similar effects on most normal cells in vitro and in vivo. The growth-inhibiting effect of these agents on cancer cells may not involve antioxidant action but may involve changes in expression of genes and levels of proteins and translocation of certain proteins from one cellular compartment to another.
ISSN:0022-3166
1541-6100