A Population Pharmacokinetic Model for ^sup 51^Cr EDTA to Estimate Renal Function

The determination of CLCR requires accurate collection of urine over a 24 h period, a procedure that is not practical in most clinical settings. [...]several creatinine-based equations, such as the Cockcroft-Gault [3], Modification of Diet in Renal Disease (MDRD) [4, 5] and Chronic Kidney Disease Ep...

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Bibliographic Details
Published inClinical pharmacokinetics Vol. 56; no. 6; pp. 671 - 678
Main Authors Kuan, Isabelle H S, Duffull, Stephen B, Putt, Tracey L, Schollum, John B W, Walker, Robert J, Wright, Daniel F B
Format Journal Article
LanguageEnglish
Published Auckland Springer Nature B.V 01.06.2017
Subjects
Cancer
Clinical trials
Collaboration
Drug dosages
Epidemiology
Estimates
Kidney diseases
Methods
Pharmacokinetics
Population
Urine
New Zealand
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Summary:The determination of CLCR requires accurate collection of urine over a 24 h period, a procedure that is not practical in most clinical settings. [...]several creatinine-based equations, such as the Cockcroft-Gault [3], Modification of Diet in Renal Disease (MDRD) [4, 5] and Chronic Kidney Disease Epidemiology Collaboration (CKD-epi) [6] equations, have been developed that do not require the collection of urine samples. Model selection was made based on (1) a reduction in objective function value (OFV) of 3.84 units (Chi-square [V ], p < 0.05) for nested models with one degree of freedom; (2) graphical goodness-of-fit plots; (3) a reduction in BSV; (4) the biological plausibility of the parameter estimates; and (5) parameter precision. Daniel F. B. Wright dan.wright@otago.ac.nz Key Points The commonly used 'slope-intercept' method for estimating the isotopic glomerular filtration rate (GFR) was found to produce a positively biased estimate of GFR compared with our pharmacokinetic model predictions. Modification of Diet in Renal Disease versus Chronic Kidney Disease Epidemiology Collaboration equation to estimate glomerular filtration rate in obese patients.
ISSN:0312-5963
1179-1926
DOI:10.1007/s40262-016-0489-x