Leishmanicidal Activity of Biogenic Fe^sub 3^O^sub 4^ Nanoparticles

• Published in: Scientia pharmaceutica Vol. 85; no. 4; pp. 1 - 9
• Main Authors: Khatami, Mehrdad, Alijani, Hajar, Sharifi, Iraj, Sharifi, Fatemeh, Pourseyedi, Shahram, Kharazi, Sam, Lima Nobre, Marcos Augusto, Khatami, Manouchehr
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01.10.2017
• Subjects: Antibiotics; Antimicrobial agents; Antioxidants; Biosynthesis; Efficiency; Fourier transforms; Medicine; Metal oxides; Methods; Nanoparticles; NMR; Nuclear magnetic resonance; Spectrum analysis; Studies; Transmission electron microscopy
• ISSN: 0036-8709; 2218-0532
• DOI: 10.3390/scipharm85040036

According to the European Commission recommendations, nanoparticles are defined as manufactured materials containing particles in a free state or as an aggregate, wherein at least 50% of the particles have one or more dimensions in the range of 1-100 nm [10,11]. R. officinalis has high antioxidants [34], and it is used as a safe food flavoring due to its favorable taste and aroma [35]. [...]in this study, we aimed to evaluate the leishmanicidal efficiency of biosynthesized IONPs. 2.Material and Methods 2.1. [...]absorbance was measured by an ELISA reader (BioTekELX800, Winooski, VT, USA) at 490 nm. [...]studies are required to make these findings applicable and to adjust the iron nanoparticles such that they have special effects on cancer cells. [...]we strongly suggest further experimental works to evaluate the effect of IONPs on intra-cellular amastigotes, and a comparison of amastigotes with extracellular organisms (promstigotes), and biological activity in animal models and clinical settings. 5.Conclusions In this report, IONPs were synthesized via a green method.