Dabigatran Reversal with Idarucizumab Letter

Data provided by Pollack and colleagues (Aug. 3 issue)1 suggest a dissociation between the normalization of the coagulation profile and the establishment of effective hemostasis after the administration of idarucizumab in patients with uncontrolled bleeding. The median time to the cessation of bleed...

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Bibliographic Details
Published inThe New England journal of medicine Vol. 377; no. 17; pp. 1690 - 1692
Main Author Yip, Luke
Format Journal Article
LanguageEnglish
Published Boston Massachusetts Medical Society 26.10.2017
Subjects
Anticoagulants
Cohort analysis
Heart
Hemorrhage
Stroke
Surgery
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Summary:Data provided by Pollack and colleagues (Aug. 3 issue)1 suggest a dissociation between the normalization of the coagulation profile and the establishment of effective hemostasis after the administration of idarucizumab in patients with uncontrolled bleeding. The median time to the cessation of bleeding was 2.5 hours among patients with nonintracranial hemorrhage. In analyses reported separately, the median time to the cessation of bleeding was 3.5 hours among patients with gastrointestinal bleeding and 4.5 hours among those with nonintracranial and nongastrointestinal bleeding.2
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJMc1711337