Early heat shock protein 72 and 90Alpha intracellular and extracellular responses in patients with severe sepsis or systemic inflammatory response syndrome

Heat shock proteins (HSPs) have intracellular cytopro tective actions, while they act extracellularly as inducers of cytokines and stimulants for immune cells during stress. Their induction constitutes a highly conserved cellular defense mechanism against all kinds of stress. Our objective was to de...

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Published inCritical care (London, England) Vol. 19
Main Authors Apostolou, K, Vardas, K, Briassouli, E, Psara, K, Goukos, D, Mageira, E, Nanas, S, Routsi, C, Briassoulis, G
Format Journal Article
LanguageEnglish
Published London BioMed Central 01.01.2015
Subjects
Sepsis
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Summary:Heat shock proteins (HSPs) have intracellular cytopro tective actions, while they act extracellularly as inducers of cytokines and stimulants for immune cells during stress. Their induction constitutes a highly conserved cellular defense mechanism against all kinds of stress. Our objective was to determine the intracellular as well as extracellular levels of HSP72 and HSP90α in patients with severe sepsis (SS) or systemic inflammatory response syndrome (SIRS) admitted to a general ICU, compared with those of healthy individuals; to correlate their expression with severity of illness.
ISSN:1364-8535
1366-609X
DOI:10.1186/cc14121